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The in vitro and preclinical data suggesting direct testicular action have not yet been confirmed in large, well-powered human trials

these drugs should not be used in patients with a personal or family history of medullary thyroid carcinoma or MEN2 Rare cases of retinopathy progression in patients with pre-existing severe diabetic retinopathy, likely related to rapid glycemic improvement Potential drug interactions related to delayed gastric emptying, which can affect absorption of other oral medications The practical approach is dose titration

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Skalny AA, Tinkov AA, Medvedeva YS, Alchinova IB, Karganov MY, Skalny AV et al (2015) Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

126 Chromium The mineral chromium may benefit women with PCOS due to its ability to support glucose regulation and metabolic health