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Gallbladder disease , including cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation), occurs more frequently with tirzepatide compared to placebo, likely related to rapid weight loss and altered bile composition

Consistent weekly dosing produces the best outcomes

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October 2023: NBC News provided coverage on possible adverse reactions to Ozempic and related semaglutide medications following JAMA research publication

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