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X-ray structure of human aldo-keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis

demonstrated that a patient with chronic RE experienced sustained relief from symptoms such as abdominal pain, diarrhoea, and haematochezia following two courses of intestinal microecological transplantation, accompanied by a shift in microbial diversity and composition towards the donors profile 179

For example, 7alpha-hydroxy-5beta-cholestan-3-one is an intermediate product of primary bile acid synthesis (Offei et al., 2019)