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Seeds, W

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Acetaminophen is the number one cause of acute liver failure in the U.S

Cysteine residues can form disulfide bonds with each other or oxidize to cysteic acid

These disruptions lead to water and sodium influx, potassium efflux, cell swelling, membrane potential changes, and eventual cell lysis, which then releases intracellular contents, eliciting an inflammatory phenotype through DAMP release and triggering immune responses (Murao et al., 2021)