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Lactobacilli are lactic acid-producing bacteria capable of generating both acetate and butyrate ( Functional interactions of incretin receptors with other GPCRs To understand the function of a specific GPCR, it is fundamental to consider the context in which this receptor is signalling, including both physical and functional interactions with other co-expressed receptors (Figure 1)

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Some studies suggested that PRLR activation enhanced expression of suppressor-of-cytokine signaling (SOCS) proteins at hypothalamus including arcuate nucleus, medial preoptic area and the nucleus of the solitary tract which inhibited shared downstream signaling pathways of leptin receptor and leads to increased appetite and body weight (71)