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TNF-, IL-6) and simultaneously increases anti-inflammatory signaling in injury models

The MASH mouse and hamster work published by Briand and colleagues in 2026 showed dose-dependent reductions in body weight, hepatic steatosis, and liver enzymes that exceeded what dual agonists produced in the same models (Briand et al., Obesity, 2026)

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Peroxiredoxins Peroxiredoxins (Prxs) comprise a family of 6 mammalian cysteine-dependent peroxidase enzymes that are major regulators of the cellular redox environment, and impact protein cysteine oxidation

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