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GLP-1 plays a critical role in regulating blood sugar levels by stimulating insulin secretion from the pancreas after meals, slowing gastric emptying, and reducing appetite

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For glycemic control in type 2 diabetes, treatment is typically continued indefinitely as long as it remains effective and well-tolerated, with periodic assessment of the ongoing need for therapy

2 The main reported adverse events associated with semaglutide were gastrointestinal including nausea, vomiting, diarrhea, abdominal pain, and constipation

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Third, there is tachyphylaxis