Erratum in: J Am Coll Cardiol 2012;59(24):2306 52.Eagle KA, Berger PB, Calkins H, Chaitman BR, Ewy GA, Fleischmann KE, et al
In skeletal muscle cells, SELENOW was shown to reduce the binding of 14-3-3 to a transcriptional co-activator with PDZ-binding motif (TAZ) (23), allowing TAZ translocation to the nucleus and subsequent activation of muscle cell differentiation genes (24)
During the 1980s, Talalay began investigating the chemical properties of fruits and vegetables, reasoning that plants, over millennia of evolution, had developed thousands of chemical compounds to protect themselves against oxidation, inflammation, and DNA-damaging agents that cause diseases like cancer
Cold sensitivity and chills affect a meaningful percentage of people taking tirzepatide, a dual GLP-1 and GIP receptor agonist used for weight loss
It may be necessary to attack each of these likely causes with separate drug development programs
Hoff et al., 2024) (Fig