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The lowest dose had the greatest effect on increasing negative BOLD signal, a response that reflects a decrease in brain activity

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F.RosenthalP.et al (2011)

"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study