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We next considered the potential role of neoantigens resulting from SNVs in early disease by predicting neoantigens for patient-specific HLA-A, -B and -C alleles using NetMHC4.0 31,32 (see Supplementary Methods) and examining the loss of these predicted neoantigens due to LOH in late disease

Code availability The code that supports the findings of this study is available online at References Staner, L

doi: 10.1200/jco.20.00775 174 ChenLDouglassJKleinbergLYeXMarciscanoAEFordePMet al