In contrast, the beneficial effects of SGLT2 inhibitors on albuminuria and eGFR decline in DKD were demonstrated by EMPA-REG OUTCOME (Wanner et al., 2016), CANagliflozin cardioVascular Assessment Study (CANVAS) (Perkovic et al., 2018), DECLARE-TIMI58 (Mosenzon et al., 2019b), and Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) (Perkovic et al., 2019)
Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.Formal Name: N,N-dimethyl-methanamine, N-oxide
Can J Diabetes 2013;37:S1212
The data: 18% of US adults have tried a GLP-1 drug to lose weight, or to treat diabetes or heart disease, and 12% are currently using them, per new KFF survey data
The Cleveland clinic foundation
SOCS1: Suppressor of cytokine signaling 1