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People who smoke a lot and people without depression might get more benefit

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Additive cardiovascular risk reduction of GLP1a and SGLT2i in diabetic patients with atherosclerotic disease

Greater stability around hunger and fullness

The quite unexpected positive cardiorenal outcomes that have emerged from the cardiovascular outcomes trials (CVOTs) with both glucagon like peptide-1 receptors agonists (GLP-1RA) and sodium-glucose co-transporter 2 (SGLT-2) inhibitors have produced a shift of diabetes management from the meticulous glycemic control alone to the simultaneous improvement of CV outcomes