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This defect is caused by reduced acquisition of a neuronal phenotype and an increase in the acquisition of an astrocytic phenotype by neural progenitor cells (J

ACS Appl

Only 2 (5.4%) patients had fibrosis regression

Patients have reported patchy skin color (where different areas of the skin have different tones) and premature graying of hair due to the significant reduction of melanin

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The most worrisome possibility is that of impaired blood clotting, which increases the likelihood of hemorrhage in some individuals