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Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes
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This additive effect on energy expenditure is why the retatrutide dosage range studied (112mg weekly) produced weight loss outcomes that exceeded all prior incretin-class compounds in head-to-head timelines
To date, liraglutide, and the more effective once-weekly semaglutide, have been approved in the US and Europe for the treatment of obesity, with unprecedented weight loss of up to 1520%
For once-weekly GLP-1 medications, follow your medications specific prescribing information.GLP-1s allows changing your injection day if at least 2 days (48 hours) have passed since your last dose
