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Furthermore, understanding the mechanisms underlying solubility in mixed solvents and developing predictive models can streamline formulation development and reduce the time-to-market for safer and more effective therapies 21,22

[1] [4] When B12 is deficient, myelin production is impaired, leading to demyelinationthe breakdown of this protective sheathwhich results in abnormal nerve signalling perceived as pain, tingling, or numbness

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While neither of these fits are perfect, they at least allow estimation of the thermodynamic parameters of the binding reaction

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