Durcan R, Wiblin L, Lawson RA, Khoo TK, Yarnall AJ, Duncan GW, Brooks DJ, Pavese N, Burn DJ (2019) Prevalence and duration of non-motor symptoms in prodromal Parkinsons disease
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Most patients benefit from starting at lower doses and gradually moving higher over weeks to months, allowing the body to adapt and improve tolerability
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Intriguingly, it was found that males, but not females, showed an UA-related enrichment of methylation sites in genes involved with neuroprotective pathways 63
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