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Evidence confidence is Low to Very Low

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GLP-1 medications are not recommended during pregnancy or breastfeeding, and some (like semaglutide) should be discontinued at least 2 months before a planned pregnancy

These crystals can physically damage the protein molecules and disrupt the pens delivery system, making the medication unsuitable for use

Gastrointestinal adverse events including nausea, vomiting, and diarrhea are common with current GLP-1 agonists, leading some patients to discontinue treatment or fail to reach maximally effective doses

The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipationsymptoms that can be particularly problematic in Parkinson's patients who often already experience autonomic dysfunction and gastroparesis