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96% of animals (22/23) receiving autonomous delivery showed semaglutide in systemic circulation at clinically relevant levels for up to ten days following administration

This study suggests that GLP-1 can enhance the function of brown fat, increase heat production in BAT, and reduce body weight in mice by modulating the activity of the sympathetic system through binding with GLP-1R in the center

These findings could help researchers develop more effective therapies and potentially extend the benefits of existing GLP-1 medications

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74 For instance, in the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial, weekly semaglutide administration resulted in a mean body weight reduction of 14.9% from baseline among overweight or obese non-diabetic individuals, 76 a magnitude of weight loss previously observed only following bariatric surgery