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Hemolysis with an increased rate of red blood cell destruction is commonly due to inherited blood disease but can also be acquired or due to infection, including: Thalassemia is a genetic blood disorder caused by defective hemoglobin synthesis in red blood cells, resulting in fewer red blood cells, a shorter lifespan, and easily broken-down red blood cells

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In contrast, the masses of Leu244Arg, Asn240Lys/Leu244Arg and Asn240Thr/Leu244Arg revealed the presence of the thioether bridge and both disulfide bonds (Fig