The atherosclerotic benefits provided by GLP-1RA, which reflect the improvement of glycated hemoglobin level, blood pressure, albumin-to-creatinine ratio and other favorable hemodynamic effects, may be responsible, at least in part, for this finding
Where positive effects have been observed, the magnitude of weight loss is typically smallgenerally in the range of 0.5-2 kgwhich may not be clinically meaningful for most individuals seeking weight management
Patients can also consider filling the deflated areas with either their own fat or other products, including hyaluronic acid-based and human-derived fat products." Surgical options can help improve the appearance of the area and help reduce irritation and chaffing caused by excess skin
doi: 10.1016/j.biopha.2018.07.092 220 SinghSChangHYRichardsTMWeinerJPClarkJMSegalJB
Even though GLP-1s were initially studied for their role in insulin secretion regulations, we now know that they have actions across different organs, and they are also widely expressed in the brain, raising the possibility that they may have direct [central nervous system] effects, Afsaneh Shirani, MD, board certified neurologist at Saint Luke's Marion Bloch Neuroscience Institute and the University of Missouri-Kansas City, told attendees
Rising utilization and costs The high cost is driven not only by the price of these drugs, but also by their expanded use for other conditions associated with cardiometabolic disease, such as obstructive sleep apnea
