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The combination of linaclotide's pro-secretory effects and semaglutide's variable impact on bowel habits could result in unpredictable stool patternsranging from severe diarrhoea to alternating bowel habits

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Because Rybelsus requires specific administration conditions (empty stomach, 30-minute wait), attempting to take a missed dose later in the day is not recommended and is likely to result in reduced absorption and effectiveness

Effect of Subcutaneous Semaglutide vs

Carone et al., 2016