Since co-treatment of UK-5099 and JMF4073 depleted dTTP pool and suppressed the growth of T315-Bcr-Abl-32D cells, we proposed that reducing GSH biosynthesis induces not only oxidative stress but also replication stress in tumor cells, which demands the synthesis of dTTP and dCTP for survival
Parasite recognition and signaling mechanisms in innate immune responses to malaria
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When cytoplasmic concentrations of neurotransmitters rise dangerously high, TAAR1 activates G-protein-dependent signaling pathways that recruit intracellular kinases, including protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII) (Underhill et al., 2020)