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Administration of a general anaesthetic will substantially reduce food intake, because the subject is asleep, but this does not mean that it regulates intake or would be a sensible drug to reduce obesity
Petersen KF, Shulman GI
doi: 10.1073/pnas.94.15.7915 18 IrwinDMHunerOYousonJH
doi: 10.1161/JAHA.118.009379
it has only recently been appreciated that the gut has the capacity to detect intraluminal contents in much the same way as the tongue, via activation of specific G-protein-coupled receptors, and that ensuing signaling mechanisms modulate the release of an array of gut hormones that influence gastrointestinal motility, appetite and glycemia
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