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352 In LPS/IFN--induced inflammation models, lipid peroxidation levels are increased, and GPX4 expression is significantly reduced, promoting ferroptosis in intestinal epithelial cells

Nussbaum-Krammer CI, Neto MF, Brielmann RM, Pedersen JS, Morimoto RI

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A potent oxidizing agent produced in cells is hydrogen peroxide, which can lead to more drastic, irreversible chemical modifications of Cys side chains