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British Medical Journal

Enzymes, pH fluctuations, and the liver's first-pass metabolism can all dramatically reduce the bioavailability of a compound

PMID 25024695

It is the most often used delivery technique for the continuous release of API into the deep layer of the skin

10 mg Vial Reconstitution BAC water added 2 mL Concentration 5,000 mcg/mL 250 mcg dose volume 0.05 mL = 5 units 500 mcg dose volume 0.10 mL = 10 units Doses per vial at 250 mcg 40 BAC water added 3 mL Concentration 3,333 mcg/mL 250 mcg dose volume 0.075 mL = ~7.5 units 500 mcg dose volume 0.15 mL = 15 units Doses per vial at 250 mcg 40 Units shown are U-100 insulin syringe units (where 100 units = 1.0 mL)