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Bis DOCA-ethylenediamine ( bis DOCA) was conjugated with activated DOCA (16.85 mmol) using 4-MMP (16.85 mmol) and lys(BOC)OMe

Given the lack of liver GLP-1R expression (136), the potential mechanism of actions of GLP-1R agonists in NASH may be related to the indirect beneficial effects on body weight, IR and reduction in metabolic dysfunction, lipotoxic effects and inflammation (137)

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