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Trial participants spanned diverse demographics including various ages, body weights, and ethnic backgrounds

The largest reduction in the ICER was observed when applying a second treatment intensification step to basalbolus insulin at an HbA1c switching threshold of 7.5% (58 mmol/mol), which resulted in increased clinical benefits and reduced incremental costs with oral semaglutide and an ICER of GBP 4316 per QALY gained

This suggests that a primary difference between the GF and SM protocol in terms of their individual effect on iPSCs during differentiation is the extent of metabolic rewiring and maturation in the HLCs

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Nature Communications, 11(1), 4413

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