The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)
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Since changes in bone tissue manifest as fractures with a long delay, this may hint at more pronounced slow-acting effects on bone of the two drugs, although imbalances in confounding factors between the groups may also arise as time passes
- 1500-2000
Rybelsus (daily pill, for type 2 diabetes): often starts at 3 mg by mouth once daily for 30 days, then is increased
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