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"LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes and obesity: a randomised, double-blind, ascending dose phase 1 clinical trial." The Lancet 392.10160 (2018): 2180-2193

Managing common side effects Most GLP-1 side effects can be managed with simple, practical strategies

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19-25 The GLP-1 RA and insulin secretagogue/insulin doses can subsequently be titrated on the basis of individualized needs to achieve the desired level of glycemic control

Sustained elevation above the normal range carries theoretical concerns regarding cell proliferation, and tesamorelin is contraindicated in individuals with active malignancy

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