First articulated in 1995 by Williams and Tabas (227), the hypothesis was based on more than two decades of work demonstrating that apoB-containing lipoproteins are retained in the artery wall by interaction with proteoglycans (228,229)
A recent CDC study (Smith et al 2011) carried out a genome-wide mapping of gene SNPs and gene expression in 40 CFS patients and 40 controls
Potential mechanisms include improvements in blood pressure, lipid profiles, body weight, inflammation, and endothelial function as well as direct cardioprotective effects on the cardiac muscle and vasculature [41]
Key near-term catalysts include U.S
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