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In rodent models, both GLP-1 and exendin-4 appear to influence reproductive efficiency via interaction with the hypothalamic kisspeptin (Kiss-1) system (Outeirino-Iglesias et al., 2015)

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LVEF = left ventricular ejection fraction

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Our observations are consistent with a previous clinical study in solid tumors where continuous infusion of BSO depleted tumor GSH below 10% of pretreatment levels with minimal systemic toxic effects