Activated microglia release nitric oxide and other mediators that, when combined with superoxide, form peroxynitrite, a highly reactive species capable of damaging proteins, lipids, and DNA
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The effect largely depends on the type of filler, the injection technique, and the anatomical area treated
In this review, we synthesize clinical and preclinical evidence demonstrating that KP dysregulation constitutes a convergent mechanism linking stress, inflammation, excitotoxicity, and oxidative stress in MDD, and critically evaluate its potential as a source of biomarkers and therapeutic targets (see Fig
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