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Nat Rev Cancer 2022;22:381-96
RNAs get converted to DNAs in the presence of Ribonucleotide Reductase, and for that hydrogen, a source is needed, NADPH
48 The ability of the few remaining disc cells to repair the damage of a vast matrix is further reduced by altered matrix stresses

Guest Episode Womens health and performance: how training, nutrition, and hormones interact across life stages Guest Episode Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards Podcast Episode Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment Guest Episode The science of resistance training, building muscle, and anabolic steroid use in bodybuilding Guest Episode A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions Guest Episode Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use AMA Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent Guest Episode The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods AMA Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins AMA GLP-1 Agonists The Future of Treating Obesity

Some women find that stepping back to a lower dose and titrating up more slowly resolves the issue without sacrificing weight loss efficacy