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MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species

The concept that Nrf-nuclear factors may control GPx-1 expression (directly or indirectly) is supported by other studies that correlate Nrf1-responses with increased expression of GPx-1 (168)

Epidemiology of Parkinson's disease

Long-term functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp

When levels drop below optimal ranges, the body signals distress through fatigue, weakness, and neurological complications

And that's sort of defined by the endocrine society, looking at a lot of different aggregate studies and all-cause mortality, for example