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When abundantly incorporated into membrane phospholipids, PUFAs greatly increase cellular susceptibility to ferroptosis due to their high autoxidation potential ( 3.1.2 Expression and regulation of key enzymes Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are key enzymes that modulate phospholipid synthesis and remodeling

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doi: 10.1056/NEJMoa2416394