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While both medications reduce appetite through different mechanismsphentermine via sympathomimetic stimulation and semaglutide through GLP-1 receptor activationthe combined effect on appetite suppression, cardiovascular parameters, and metabolic function has not been systematically studied in large populations

For the obesity cohort, the findings were even more striking, with patients showing more than sevenfold increased risk

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These actions help regulate appetite, increase feelings of fullness, and support healthier eating patterns