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The SELECT trial (2023) further demonstrated a 20% reduction in major adverse cardiovascular events, adding a cardioprotective dimension

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Tirzepatide often shows greater efficacy than semaglutide

Tesamorelin stimulates growth hormone synthesis by activating GHRH receptors on pituitary somatotrophs, while Ipamorelin amplifies GH pulse amplitude through GHSR-1a agonism the combined effect increases hormone-sensitive lipase (HSL) activity in visceral adipocytes, which have higher GH receptor density than subcutaneous fat cells

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