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doi: 10.1016/j.neuropharm.2016.12.010 71 CogramPDeaconRMJWarner-SchmidtJLvon SchimmelmannMJAbrahamsBSDuringMJ
As a Nrf2 activator, urolithin A not only protects kidney against oxidative stress via promoting Nrf2 translocating into nucleus (Zhang et al., 2022c), but also ameliorates hyperuricemic nephropathy via enhancing PINK1-associated mitophagy in renal TECs (Zhang et al., 2022a)
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Applied Biochemistry and Biotechnology, 189 , 206216
This can lead to: Puffy hands or feet Morning stiffness in the joints Mild carpal tunnel-like sensations Reducing the dose or spacing out injections may help minimize these symptoms
This breakthrough extends beyond traditional small molecules to include complex biologics as well
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