The biological plausibility of AOD9604s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production
Another strategy to alleviate disease-causing effects of autoreactive IgG is to block activating FcRs, thereby preventing pathological IgG-mediated activation of FcR-expressing immune cells
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This product does not contain L-ascorbic acid, but rather a blend of highly stable, but potent vitamin C derivatives that increase tolerability and shelf life
doi:10.1016/j.bbamcr.2015.01.021