This program evaluated the efficacy and safety of oral semaglutide in patients with DM2 from monotherapy to insulin addition, including HbA1c and body weight reduction outcomes, in addition to other relevant efficacy and safety endpoints, as compared to both placebo and other common antihyperglycemic drugs
Cell Death Discov 9(1):256 Jia G, Hill MA, Sowers JR (2018) Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
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In Europe, Joint Clinical Assessments under the EU HTA Regulation centralize the evaluation of clinical value at the EU level, while pricing and reimbursement remain national decisions
Second, translational tools should focus on dual-targeted nanocarriers designed to reach cerebellum and myocardiumusing TAT peptides for bloodbrain barrier penetration and CTP peptides for cardiomyocyte targetingloaded with mitochondria-directed ferroptosis modulators capable of activating GPX4 while supporting ironsulfur cluster synthesis, and released in response to GAA-repeat-dependent triggers to avoid off-target iron perturbation
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