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11 Other glucose-lowering treatments can be continued if needed for glycaemic control or cardiovascular or renal protection, with the dose of insulin or a sulfonylurea reduced to prevent hypoglycaemia, if required (see: Prescribing empagliflozin for guidance on dose reduction)

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Brain Signaling Changes That Drive Weight Loss Your brain contains multiple appetite centers that communicate through chemical messengers called neuropeptides

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and Borel, J.P