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JWU-A021 retains its ability to activate mutant C622S TRPA1 Electrophiles such as AITC activate TRPA1 channels by covalently modifying cysteine residues located near the cytosolic N-terminus of the channel 4,13

ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia/reperfusion injury

Adv Nutr 6(4):474486 Acknowledgements The authors acknowledge the use of advanced research tools for literature search and data synthesis in the preparation of this comprehensive review

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Results Organic oxidants induce ferroptosis in cardiomyocytes Oxidative stress primarily induces non-apoptotic cell death, but the cell death mechanism remains unclear 7, 22

doi:10.1016/j.nut.2004.04.003