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Endocrinology (2015) 156(11):395060.10.1210/en.2015-1361 96 TsukaharaTWatanabeKWatanabeTYamagamiHSogawaMTanigawaTet alTumor necrosis factor alpha decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease

Advanced glycation end product accumulation: a new enemy to target in chronic kidney disease

Persistent fatigue beyond 46 weeks may indicate inadequate nutrient intake, insufficient hydration, or an underlying metabolic issue unrelated to semaglutide

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Potential contributing factors may include: Changes in gastrointestinal motility Dietary changes often accompanying weight loss efforts Individual digestive system responses to the medication It is important to note that whilst these gastrointestinal effects are common, they do not indicate that the medication is harmful to the digestive system