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This necessitates careful monitoring and likely medication adjustment
Simple timing framework Baseline Discuss baseline labs before starting, especially with diabetes, kidney disease, gallbladder history, pancreatitis history, liver disease, or cardiovascular concerns
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10.1016/j.redox.2013.01.007 Redox Biol
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[6] Preclinical studies in animal models suggest that GLP-1 receptor activation may: Promote neuroplasticity and neurogenesis (formation of new neurons) in the hippocampus, a region often showing reduced volume in depression Modulate neurotransmitter systems , particularly dopamine and serotonin pathways involved in mood regulation and reward processing Reduce neuroinflammation , which is increasingly recognised as contributing to depressive disorders Enhance brain-derived neurotrophic factor (BDNF) expression, a protein crucial for neuronal health and resilience Metabolic improvements associated with GLP-1 therapy may also contribute indirectly to mood benefits
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