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Retrieved August 7, 2024

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GLP-1 effects are mediated through binding to the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR) that signals primarily through the stimulatory G protein G s

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This represents the first head-to-head comparison between incretin therapies in a cardiovascular outcomes trial

Her work suggests that differences in brain access and signaling may help explain why patients with type 2 diabetes often experience less weight loss than non-diabetic patients on the same drugs