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This disease most often develops when other factors such as diabetes, kidney failure, or therapy with certain drugs are present

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Their openness is actively regulated, and one of the key regulators is a protein called zonulin , which controls the movement of molecules across the gut lining

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(For more on this, read Stay Sharp in The Offseason By Following the Way of the Farmer , available here on the NCOAE Blog.) The industry standard when traveling with groups on guided trips in the backcountry is the use of chemical treatment, typically Iodine