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The high abundance of SFAs, secondary to increased FASN activity, is incorporated into membrane phospholipids, rendering cells less susceptible to free radicals and therapeutic penetration (76)

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748 Inhibition of this pathway using the PAR1 antagonist vorapaxar has been shown to reduce the burden of senescent cells, offering a potential therapeutic strategy

Butterworth-Heinemann, Boston, pp 11951230 Dallas S, Zhu X, Baruchel S, Schlichter L, Bendayan R (2003) Functional expression of the multidrug resistance protein 1 in microglia