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Originally identified in intestinal stem cells, LGR5 is now recognized as a marker of CSCs in GBM, colorectal, gastric, and hepatocellular cancers, where its expression is correlated with increased tumor initiation, metastatic potential, and poor prognosis

EGFR activation helps RPE cells regenerating damaged areas and maintaining blood-retinal barrier

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Flu like symptoms can last up to 24 hours when given IV

In vivo studies on murine models confirm the above results and highlight the drug's long-lasting weight-reduction effects