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3.3.3 Effect of metformin on birth weight in offspring of patients with polycystic ovary syndrome The progression of the placenta and fetus necessitates a heightened oxygen demand and the presence of fully developed mitochondria in the later stages of pregnancy to facilitate the transportation of essential nutrients for fetal development ( in utero and drug exposure may play a role in the development of obesity
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[2] [3] This mechanism has several physiological effects that contribute to glycaemic control, with appetite reduction and weight loss occurring as secondary effects
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