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In brief, berberine can reduce anti-apoptotic factors (Bax/bcl-2, caspase), autophagy related proteins (IL-3, Beclin, etc.), A pathology, and activate PI3K-AKT and other signaling pathways, and then produce neuroprotective effect (Figure 1)

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[175] reported that luteolin decreased the expression of Beclin1, LC3II/LC3I, IL-17a, and RORt but increased the expression of IgG2a, IL-10, and Foxp3 in AR mice

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